Design, Synthesis, Characterization, Docking studies and Antibacterial evaluation of Novel Bipyrazole derivatives
DOI:
https://doi.org/10.61096/ijpar.v10.iss1.2021.54-70Keywords:
Bipyrazoles, Fabh-in silico, Anti-bacterial activityAbstract
Bis-heterocycles especially those containing pyrazole moiety display much better antibacterial activity than monoheterocycles. So, a new series of Bi pyrazole derivatives were synthesized by using 4-substituted acetophenone and phenyl hydrazine. The newly synthesized compounds were characterized by IR, 1 H NMR, and 13C NMR analytical data. And evaluated for Anti-bacterial activity, based on the in-silico evaluation of docking study on Fabh using 4VB as a control inhibitor, among all the four compounds the 7b has shown more significance in the activity than the others. That have been confirmed by Anti-bacterial in-vitro study.