Formulation and evaluation of combination porous tablet containing naproxen sodium as immediate release and sumatriptan succinate as sustained release

Abstract

Migraine is a chronic disorder and characterized by splitting headaches. A combination of sumatriptan succinate and
naproxen sodium was found to be effective. Time to reach Cmax and biological half-life of both drugs are different and hence
optimum levels of both drugs cannot be maintained simultaneously in the blood when these drugs administered orally in the
form of conventional tablet. Therefore the object of present study was formulation development in vitro evaluation of porous
combination tablet dosage form containing Naproxen sodium as immediate release in 45min and sumatriptan succinate as
sustained release to maintain optimum plasma levels of both drugs at a time and for a prolonged period of 12hrs. And here
using sublimating agents camphor, and superdisintegrants like SSG for immediate release and HPMC K100M polymer to
sustain the drug release.