Influence of ethylcellulose on release of lamivudine from HPMC K4M transdermal patches

Abstract

The purpose of the present research was to formulate HPMC K4M based lamivudine transdermal patches and to study the
influence of ethyl cellulose on its characteristics. TDDS formulations were prepared and characterized for the tensile
strength, percentage elongation, water vapour transmission studies (WVT), water vapour absorption studies (WVA),
FTIR, SEM, and in vitro drug release kinetics. The prepared patches showed good elasticity. The IR spectral studies
showed that the drug remained in its normal form without undergoing any interaction with the polymers. The optimized
formula based on drug release (F5) showed drug dissolution of 98.72% after 14 h.