Analytical method Development and Validation for the estimation of Pioglitazone hydrochloride in Bulk and Tablet dosage form by UV_Spectroscopy

Abstract

This paper describes the analytical method suitable for validation of Pioglitazone hydrochloride by UV Spectrophotometric method. The method utilized UV spectroscopy  and the solvent system was consists of 6 N Glacial acetic acid at wave length 270 nm. Validation  experiments  were performed  to demonstrate  Specificity, Precision, Linearity, Accuracy, ruggedness. The method was linear over the concentration range of 10-50 µg/ml. The Proposed method was simple, sensitive & reliable with good Precise, Accurate, and Reproducible  and rapid for the determination  of Pioglitazone.  The commercial  formulations  are estimated  without interference.  Hence this   method   can   be   used   for   routine   determination   of   Pioglitazone   hydrochloride   in   bulk   and   their pharmaceutical  dosage forms.