Synthesis, Characterization and Biological evaluation of substituted Pyrazole derivatives

Abstract

The work presented in this article consists of synthesis, characterization and biological evaluation of substituted
pyrazole derivatives. Pyrazole derivatives have been shown to have wide variety of pharmacological activities
like antimicrobial, antiviral, antihistaminic, antitumor, antipyretic, anti-inflammatory, antidepressant and
anticonvulsant. As combination of biologically active moieties into one molecule and synthesis of totally newer
moieties have been the methods of research, we present here synthesis of some novel pyrazole derivatives
incorporating various biologically active aryl/aryloxy acid derivatives such as ibuprofen, diclofenac, aceclofenac
as well as potent antibacterial quinolones, norfloxacin and ciprofloxacin. All the compounds synthesized were
evaluated for their antimicrobial activity.