Formulation and Evaluation of Moxifloxacin Loaded Alginate Chitosan Nanoparticles

Authors

  • R.Devi damayanthi
  • Dr.C.B.Tharani
  • Dr.N.Narayanan

DOI:

https://doi.org/10.61096/ijpar.v2.iss4.2013.164-168

Keywords:

Moxifloxacin, Nanoparticles, Tuberculosis, Ionic gelation method, Alginate

Abstract

The main objective of this study was to prepare and evaluate Alginate chitosan nanoparticles containing
Moxifloxacin by ionic gelation method. The influence of different experimental parameters on the entrapment
efficiency (EE), drug loading (DL), rate of recovery, percent drug released etc was evaluated. SEM indicated
that nanoparticles have discrete spherical structure without aggregation. The average particle size was found to
be 105.2±8nm. The in vitro drug release behaviour from all drug loaded batches was found to be sustained
release over a period of 96 hours. Nanoparticles were stored at different temperatures and humidity as per ICH
guidelines to check the stability.

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Published

2013-11-04

How to Cite

R.Devi damayanthi, Dr.C.B.Tharani, & Dr.N.Narayanan. (2013). Formulation and Evaluation of Moxifloxacin Loaded Alginate Chitosan Nanoparticles. IJPAR JOURNAL, 2(4), 164–168. https://doi.org/10.61096/ijpar.v2.iss4.2013.164-168

Issue

Vol. 2 No. 4 (2013): 2013 Volume - 2 Issue - 4

Section

Articles