Cytotoxic activity and molecular docking studies of 9H-pyrido[3,4-b] indole derivatives

Authors

  • Alivelu Samala Department of Pharmaceutical Chemistry, Holy Mary Institute of Technology and Science-College of Pharmacy, Bogaram-Ghatkesar Rd, Kondapur, Telangana, India, 501301. Centre for Pharmaceutical Sciences, Inst of Science and Technology, JNT University, Hyderabad, Kukatpally, Telangana, India, 500085.
  • Krishna Mohan Gottumukkala Centre for Pharmaceutical Sciences, Inst of Science and Technology, JNT University, Hyderabad, Kukatpally, Telangana, India, 500085.
  • Srinivasa Murthy M Department of Pharmaceutical Chemistry, Vignan Institute of Pharmaceutical sciences, Near Ramoji Film City, Deshmukhi, Yadadri-Bhuvanagiri, Telangana, India, 508284.

Keywords:

Cytotoxic activity, Molecular docking, 9H-Pyrido[3,4-b]indole, EGFR tyrosine kinase, MTT assay.

Abstract

In the current study, we report the in vitro cytotoxic activity and molecular docking studies of a 9H-Pyrido[3,4-b]indole derivatives. Molecular docking studies were performed to determine the protein-ligand interactions. All the compounds were docked with EGFR tyrosine kinase and the data reveals that all the synthesized compounds have good binding affinity ranging from -4.46 to -3.01 Kcal/mol. Further, Cytotoxic activity was tested by MTT assay against human breast cancer cell lines (MCF7) and human cervical cancer cell lines (HeLa), using Cisplatin as a standard drug. All the tested compounds showed IC50 values in the range of 12.81±0.43 µg/ml to 31.27±0.23 µg/ml and 20.43±0.25 µg/ml to 37.28±1.02 µg/ml against MCF7 cell lines and Hela cell lines respectively.

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Published

2022-12-17