Cytotoxic activity and molecular docking studies of 9H-pyrido[3,4-b] indole derivatives

Abstract

In the current study, we report the in vitro cytotoxic activity and molecular docking studies of a 9H-Pyrido[3,4-b]indole derivatives. Molecular docking studies were performed to determine the protein-ligand interactions. All the compounds were docked with EGFR tyrosine kinase and the data reveals that all the synthesized compounds have good binding affinity ranging from -4.46 to -3.01 Kcal/mol. Further, Cytotoxic activity was tested by MTT assay against human breast cancer cell lines (MCF7) and human cervical cancer cell lines (HeLa), using Cisplatin as a standard drug. All the tested compounds showed IC₅₀ values in the range of 12.81±0.43 µg/ml to 31.27±0.23 µg/ml and 20.43±0.25 µg/ml to 37.28±1.02 µg/ml against MCF7 cell lines and Hela cell lines respectively.