Method development and validation for telmisartan in bulk and tablet dosage form by uv-spectrophotometric method

Authors

  • Nagu nath S HOD & Associate Professor, Smt. Sarojini, Ramulamma College of Pharmacy, Mahabubnagar, 509001
  • R.Arun kumar yadav Student, Smt. Sarojini, Ramulamma College of Pharmacy, Mahabubnagar, 509001
  • B. Aishwarya Student, Smt. Sarojini, Ramulamma College of Pharmacy, Mahabubnagar, 509001
  • Abdul kaleem taj Student, Smt. Sarojini, Ramulamma College of Pharmacy, Mahabubnagar, 509001
  • D. Shireesha Student, Smt. Sarojini, Ramulamma College of Pharmacy, Mahabubnagar, 509001
  • Myadam Sunitha Student, Smt. Sarojini, Ramulamma College of Pharmacy, Mahabubnagar, 509001

Keywords:

Telmisartan, Methanol, UV- Spectrometer, ICH Validations

Abstract

The main objective was to develop and validate the UV- spectrophotometric method for the estimation of telmisartan in bulk and pharmaceutical formulations as per ICH guidelines. A simple, rapid, accurate, and economical UV-spectrophotometric method has been developed for the estimation of telmisartan from bulk and pharmaceutical formulation. The λmax of telmisartan in methanol was found to be 298 nm. The drug follows linearity in the concentration range 2–10 μg/ml with a correlation coefficient value of 0.9956. The proposed method was applied to pharmaceutical formulation and % amount of drug estimated was 99.19% and was found to be in good agreement with the label claim. The accuracy of the method was checked by recovery experiment performed at three different levels, i.e., 50%, 100%, and 150%. The % recovery was found to be in the range of 98.54 – 99.98%. The low values of % RSD are indicative of the accuracy and reproducibility of the method. The precision of the method was studied as an intraday; interday variations. The % RSD value < 2 indicates that the method is precise.

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Published

2022-12-19