Estimation of Pioglitazone hydrochloride in Bulk and Pharmaceutical dosage form by UV- Spectroscopy

Abstract

A simple, fast and reliable Spectrophotometric method was developed for determination of Pioglitazone hydrochloride  in bulk and Pharmaceutical  formulation. Spectrophotometrically, Pioglitazone hydrochloride  was determined by measuring the maximum absorption at 270nm. Analytical Calibration curves were linear within a concentration  range  from  10  to  50µg/ml.  The  developed  method  was  applied  to  directly  and  easily  to  the analysis of the pharmaceutical  tablet preparations.  % R.S.D was found to be 0.51 for piosis 30 mg Tablet. The %R.S.D  values  for all method  validation  parameters  were  found  within  2% for the developed  method.  The method was completely  validated.  The results showed that this method can be used for rapid determination  of Pioglitazone  hydrochloride  in bulk and Pharmaceutical  tablet  formulation  with linearity,  precision,  accuracy specificity.