Development and validation of HPLC method for the estimation of Escitalopram oxalate in tablets.

Authors

  • N. Ramathilagam Department of Pharmaceutical Analysis, Smt Sarojini Ramulamma College of Pharmacy, Mahabubnagar, Andhrapradesh, India.
  • N. Padmaja MRM College of Pharmacy, Hyderabed, Andrapradesh, India.
  • H.S.Amarnadh MRM College of Pharmacy, Hyderabed, Andrapradesh, India.

DOI:

https://doi.org/10.61096/ijpar.v2.iss1.2013.1-6

Keywords:

HPLC, Escitoparm (ESP), Method development and Validation.

Abstract

A simple, specific,  robust, accurate  and precise isocratic  HPLC method has been developed  and subsequently validated for simultaneous determination of escitalopram (ESP) in pharmaceutical dosage forms. Kromosil (250x4.6)mm  5µ with flow rate of 1ml/ min by using JASCO PU-1580 and UV/VIS JASCO UV-1570 at 238 nm.  The  separation  was  carried  out  using  a  mobile  phase  consisting  of  acetonitrile,  methanol  and  5mM ammonium  acetate buffer (pH 3.0) in the ratio 30:20:50  respectively.  The retention time for escitaloparm  was found to be 5.36 minutes  respectively.  The correlation  coefficient  was found  to be 0.9997  (ESP).  The mean percentage recovery was found to be 101.86 respectively.  The % estimation of the drugs was found near to 100 % representing the accuracy in the method. The proposed method was also validated and applied for the analysis of drugs in tablet formulation.

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Published

2013-02-15

How to Cite

N. Ramathilagam, N. Padmaja, & H.S.Amarnadh. (2013). Development and validation of HPLC method for the estimation of Escitalopram oxalate in tablets. IJPAR JOURNAL, 2(1), 1–6. https://doi.org/10.61096/ijpar.v2.iss1.2013.1-6

Issue

Vol. 2 No. 1 (2013): 2013 Volume - 2 Issue - 1

Section

Articles