Studies on Anti-HIV activity and Cytotoxicity of Wrightia tomentosa Leaf

Authors

  • Periyasamy Selvam Reghavendra Institute of Pharmaceutical Education and Research, Anantapur 515 721, AP
  • E De Clercq Rega Institute of Medical Research, Katholieke University, Leuven, Belgium

DOI:

https://doi.org/10.61096/ijpar.v1.iss1.2012.8-11

Keywords:

Wrightia tomentosa, anti-HIV activity, Indirubin, Cytotoxicity

Abstract

Wrightia tomentosa leaf extracts and its isolated compounds (isatin, indirubin and indigotin) have been studied for inhibition of HIV-1 and -2 replication in MT-4 cells. Cytotoxicity was also investigated in uninfected MT-4 cells (C-type Adult T Leukemia cells). All the extracts and isolated compounds exhibited cytotoxicity  in MT-4 cells (CC50: 8-117 μg/ml) and Indirubin  displayed  marked cytostatic  properties  in MT-4 cells (CC50:8.32±3.83 μg/ ml).

Downloads

Published

2012-12-20

How to Cite

Periyasamy Selvam, & E De Clercq. (2012). Studies on Anti-HIV activity and Cytotoxicity of Wrightia tomentosa Leaf. IJPAR JOURNAL, 1(1), 8–11. https://doi.org/10.61096/ijpar.v1.iss1.2012.8-11

Issue

Vol. 1 No. 1 (2012): 2012 Volume - 1 Issue - 1

Section

Articles