SYNTHESIS, ANTI-HIV ACTIVITY AND CYTOTOXICITY OF 2-PHENYL, 3-SULPHONAMIDO QUINAZOLIN-4 (3H) -ONES

Abstract

A series of novel 2,3-disubstitutedquinazolin-4(3H)-ones have been synthesized by condensation of 2-substituted benzo [1,3] oxazine-4-ones  and primary amines. Their chemical structures were assigned by means of spectral analysis (FT-IR and 1H-NMR).  Synthesized  compounds  were screened for in vitro antiviral activity against  HIV-1  and -2 replication  in MT-4 cells. Cytotoxicity  was also investigated  in uninfected  MT-4 cells (C-type Adult T Leukemia  cells). All the synthesized  compounds  exhibited  cytotoxicity  in MT-4 cells (CC50:1.93-87  μg/ml)  and  compound  SPB-III  displayed  marked  cytostatic  properties  in  MT-4  cells  (CC50:1.93±0.29μg/ ml).