Formulation of transdermal approach for the treatment of angina using nifedipine as a model drug

Abstract

The purpose of this research was to develop a matrix-type transdermal therapeutic system containing drug Nifedipine with different ratios of polymeric systems by the Solvent evaporation technique by using Dibutyl phthalate to the polymer weight, incorporated as plasticizer. Glycerol was used to enhance the transdermal permeation of Nifedipine.The physicochemical compatibility of the drug and the polymers studied by infrared spectroscopy suggested absence of any incompatibility. Formulated transdermal patches were physically evaluated with regard to thickness, weight variation, drug content, flatness, tensile strength and folding endurance. In-vitro drug studies of formulations were performed by using Franz diffusion cells. The results followed the release profile of Nifedipine followed mixed peppas release kinetics. However, the release profile of the optimized formulation F6 (98.87% at 12hr) indicated that the permeation of the drug from the patches was governed by a diffusion mechanism.