Formulation & in-vitro evaluation of Imatinib mesylate floating tablet using different polymers

Abstract

Aim of the study is to formulate and evaluate Imatinib floating tablets using different polymers Sodium alginate, Guar gum, HPMC K100M, and Sod. Bicarbonate, Mg.stearate, Talc in different ratios. The Analytical method development was done on the drugs molecule for gastro retentive floating matrix formulation of Imatinib mesylate by using various hydrophilic polymers. Gas generating agent sodium bicarbonate concentration was optimized. Then the formulation was developed by using different concentrations of polymers of various grades of HPMC. The formulation blend was subjected to various pre-formulation studies, flow properties and all the formulations were found to be good indicating that the powder blend has good flow properties. Among all the formulations the formulations prepared by using HPMC K4M were unable to produce desired drug release; they were unable to retard drug release up to 12 hours. The formulations prepared with Sodium alginate retarded the drug release up to 12 hours in the concentration of  100 mg (F9).The formulations prepared with HPMC K100M were also retarded the drug release for more than 12 hours. The optimized formulation dissolution data was subjected to release kinetics; from the release kinetics data it was evident that the formulation followed Higuchi mechanism of drug release.