Formulation and evaluation of floating tablets of clopidogrel bisulphate

Abstract

Clopidogrel bisulphate is a novel antiplatelet drug used in the treatment of coronary artery diseases. The main purpose of the present study was to develop a floating and sticking tablets of Clopidogrel bisulphate by using HPMC of different viscosity grades and carbopol 934P to improve the release profile of the drug for 24 hrs and target the drug to stomach via gastric retention with sodium bicarbonate as angas generation agent to promote floating. Pre compression and post compression parameters of floating tablets were evaluated for all the especially density, thickness, in-vitro buoyancy, swelling index and dissolution. The floating nature and in vitro dissolution studies were carried out in 0.1N Hcl (pH 1.2). All the prepared batches shown good in vitro buoyancy. It had been observed increase the polymer system viscosity ultimately drug release rate was decreased. The drug release from the tablets was Higuchi release model and Non-Fickian transport mechanism.