Desmodium triflorum leaf aqueous extract on streptozotocin induced Diabetic rat

Abstract

The hypoglycemic effect of aqueous extract from leaves of Desmodium triflorum (200 & 400 mg/kg) (AEDT) was evaluated by Streptozotocin-induced diabetic rats. Animals were induced for diabetes with Streptozotocin (60 mg/kg of body weight-) and treated orally with two different doses of desmodium triflorum. Glibenclamide used as standard drug. The extract showed significant (p<0.01) anti-hyperglycemic as compared to diabetic control. The AEDT 400 mg/kg show beneficial effects on blood glucose like as standard also shows significant level of secondary metabolites. Thus both dose could serve as good oral hypoglycemic agents and seems to be promising for the development of phytomedicines for diabetes mellitus.