A comparative study of simultaneous estimation of cefixime andlevofloxacin by analytical method and their validation

Authors

  • Elavarasan. N Department of Pharmaceutical Chemistry, S. A. Raja Pharmacy College, Raja Nagar, Vadakangulam, Tirunelveli, Tamil Nadu, India
  • Shankarananth. V Department of Pharmaceutical Chemistry, S. A. Raja Pharmacy College, Raja Nagar, Vadakangulam, Tirunelveli, Tamil Nadu, India
  • Revathi. S Department of Pharmaceutics, Sri BalajiVidhyapeeth Deemed University, Puducherry, India

Keywords:

Cefixime, Levofloxacin, Spectrophotometric method, validation

Abstract

This work is concerned with the simultaneous estimation of Cefixime and Levofloxacin in a marketed  drug  by UV spectrophotometric method. Methanol as mobile phase. Detection was performed densitometrically at 230 nm and 298 nm.  The method was validated for linearity, accuracy, precision, LOD and LOQ and assay.Accuracy (100.6 ± 0. 7 % for Cefixime and 100.7 ± 1.1 % for Levofloxacin) and assay (101.3 % for Cefixime and 101.6% for  Levofloxacin)in accordance with ICH guidelines. The method is simple, accurate, and rapid and can therefore be used for routine analysis of both drugs in quality control laboratories.

Downloads

Published

2023-10-06

How to Cite

Elavarasan. N, Shankarananth. V, & Revathi. S. (2023). A comparative study of simultaneous estimation of cefixime andlevofloxacin by analytical method and their validation. IJPAR JOURNAL, 12(4), 521–530. Retrieved from https://ijpar.com/ijpar/article/view/720

Issue

Vol. 12 No. 4 (2023): 2023 Volume - 12 Issue - 4

Section

Articles