Formulation, development and evaluation of oral disintegrating tablets of lacidipine

Abstract

The aim of this study is to formulate and significantly improve the bioavailability and reduce the side effects of oral disintegrating tablets Lacidipine. The precompression blends of Lacidipine were characterized with respect to angle of repose, bulk density, tapped density, Carr’s index and Hausner’s ratio. The precompression blend of all the batches indicates well to fair flowability and compressibility. Oral disintegrating tablets were prepared with various disintegrants like Crospovidone, Croscarmellose sodium, Sodium starch glycolate at different concentration ratios and were compressed into tablets. The formulated tablets were evaluated for various quality control parameters. The tablets were passed all tests. Among all the formulations F4 formulation containing, drug and Crospovidone showed good result that is 98.46% in 30 min. Hence from the dissolution data it was evident that F4 formulation is the better formulation. By conducting further studies like in vivo studies, preclinical and clinical studies we can commercialize the product