Sustained drug delivery of microspheres containing entecavir by Ionotropic gelation technique

Abstract

In our current research work,we primarily focused on the designing of microspheres containing Entecavirusing PLGA (Poly lactic-co-glycolic acid)and Chitosanas polymers to deliver Entecavir via oral route of adminstration. The results of this investigation indicate that Inotropic gelation technique can be successfully employed to fabricate Entecavir microspheres. In this work an effort has been made toformulate microsphere of Entecavirby using different polymers.Prepared formulations are evaluated for bulk density, tapped density, precentmucoadhesion, Percent compressibility, hausners ration, percentage yield, sizeand interaction study by FTIRand in vitro drug release. Formulation has shown significant results in all the evaluation parametersand considered as best formulation of Entecavir. The formulationsF1, F2, and F3 containing PLGA showed a maximum release of97.58% at 10 hours, 98.12%  11 hours, 99.88% 12 hours  respectively.The present study reveals that Entecavir microsphere formulation by ionic gelation method could bea conducive method which delivers an excellent bioavailability to the fabricated drug