Formulation and evaluation of microspheres encompass nifedipine by solvent evaporation method

Abstract

Basically, oral route drug administration is far the most preferable route for taking medications. However, their short circulating half-life and restricted absorption via a defined segment of intestine limits the therapeutic potential of many drugs. Such a pharmaco kinetic limitation leads in many cases to frequent dosing of medication to achieve therapeutic effect. Rational approach to enhance bioavailability and improve pharmacokinetic and pharmacodynamics profile is to release the drug in a controlled manner and site-specific manner. Hence only our current research work is to prepare Nifedipine microspheresusing Solvent evaporation method using different polymer ratio. FT-IR studies revealed that there was no chemical interaction between the drug and polymer. The in vitro mucoadhesion study was conducted for all the formulations and the results were found in the range of 73.05 to 99.72%.The average particle size of the optimized formulation was found to be 166μm. The in-vitro release behavior from all the Nifedipine microsphereswas found to be peppas drug release kinetics and produced a sustained release over a period of 12 hours with better entrapment efficiency.