Formulation development and invitro characterization of dolutegravir sustained release matrix tablets

Abstract

 In our contemporary research work, constant effort has been put into deciding on herbal polymers such as Tragacanth, Acacia gum, and Thickener as obstructive polymers to allow design sustained launch capsules of Dolutegravir. All best subjected formulations limits had been fulfilled or passes the tests by means of the tablets after they had been set up, and their release kinetics effects are remarkable. Drug Excipient Compatibility studies revealed that there was no considerable change. FT-IR studies resulted that all peaks corresponding to different functional groups of pure drug were present in the drug-excipient mixtureno interaction between the dmg and excipients. To be specific the F2 formulations. Tragacanth, used to be proven to have the best drug delivery trait (99.19%) amongst all the formulations examined (12 hours). After the F2's more desirable formulation, used to be formulated.