Formulation And Evaluation Of Floating Microspheres Of Repaglinide By Ionic Gelation Method

Abstract

The  objective  of  the  present  study  was  to  Prepare  the  alginate  microspheres of Repaglinide (model drug) using calcium chloride as a crosslinking agent by inotropic gelation method. Microspheres were prepared by using 2%, 2.2% sodium alginate concentrations. Polymers (HPMC, Ethyl cellulose, Carbopol 934P) were used in combination concentration to prepare Microspheres. Microspheres were evaluated for micromeritic properties like angle of repose, bulk density, tapped density, Carr’s index, Hausner’s ratio and for drug content. The in vitro drug release study was done for microspheres All formulations. The mean particle size,  In vitro Buoyancy, Encapsulation efficiency %, Percentage yield (%) were within limits. Among all formulations of floating microspheres F7 was considered as optimised for floating microspheres. From the release kinetics data, it was evident that floating optimised formulation follows Peppas release kinetics.