Formulation and invitro evaluation of phenytoin orally disintegrating tablet by using direct compression method

Authors

  • K. Shobana Department of Pharmsceutics, Jaya College of Pharmacy, Chennai, Tamil Nadu, India
  • A. Punitha Department of Pharmsceutics, Jaya College of Pharmacy, Chennai, Tamil Nadu, India

Keywords:

Orally disintegrating tablets, Direct Compression Technique, Phenytoin, Ludiflash, FTIR

Abstract

An Orally disintegrating tablet disperses readily in saliva and the drug is available in solution or suspension form for the immediate absorption and resulting in rapid onset of action. In the present research work Phenytoin Oral disintegrating tablets were prepared by Direct Compression Technique using varying concentrations of Lycoat, Croscarmellose sodium and Ludiflash as super disintegrants. The formulations prepared were evaluated for precompression & post compression parameters. Form the drug excipient compatibility studies we observe that there are no interactions between the pure drug (Phenytoin) and optimized formulation (Phenytoin+ excipients) which indicates there are no physical changes. Post compression parameters was found to be within the limits. Among the formulation prepared the tablet containing concentration of Ludiflash shows 98.85±1.46% of the drug release within 60 min & follows first order kinetics. The overall result indicated that the formulation F12 containing Ludiflash is better and fulfilling of the needs of the Orally disintegrating tablet.

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Published

2024-05-08

How to Cite

K. Shobana, & A. Punitha. (2024). Formulation and invitro evaluation of phenytoin orally disintegrating tablet by using direct compression method. IJPAR JOURNAL, 13(2), 146–156. Retrieved from https://ijpar.com/ijpar/article/view/758