Development and screening of topical herbal cream formulations for wound healing activity

Abstract

The aim of the present work is to develop and standardize the topical herbal cream formulations using well documented herbs. Topical herbal cream formulations were prepared by using ethanol extract of Tridax procumbens  and petroleum  ether extract  of Cassia occidentalis  and mixed  extracts  of both the plants.  The above plants are traditionally used for healing of cuts and wounds. Crude raw materials of Tridax procumbens (leaf) and of Cassia occidentalis (leaf) were collected, shade dried, grinded separately and the moisture free materials were sieved through 100 mesh. The physiochemical  constants like ash values and extractive values were carried out for both the crude drugs. The aqueous extracts were prepared by maceration method and the extracts were formulated into a topical cream formulations individually and combination of both. The prepared cream formulations  were screened for their wound healing activity by excision. The wound healing activity was carried out for the formulations using betadine 5% w/w cream as standard drug. The present study was observed that the prepared topical herbal cream formulations showed significant wound healing activity.