Development Optimization Characterization of Penciclovir Loaded Solid Lipid Nanoparticle for Enhancement of Oral Bioavailability

Authors

  • B. Arunprasath Research Scholar, JJTU, Rajasthan
  • Abhinandan Danodia Assistant Professor, JJTU, Rajasthan
  • Dibya lochan Mohanty Associate Professor, School of Pharmacy, Department of Pharmaceutics, Anurag University, Hyderabad, India

Keywords:

solid lipid nanoparticle; Penciclovir; entrapment efficiency; particle size; Precirol ATO 5.

Abstract

The current study was undertaken to develop solid lipid nanoparticles (SLN) of a hydrophilic drug Penciclovir and improve the entrapment efficiency of the drug in SLN. The SLN were prepared with Precirol ATO 5   as lipid using solvent-evaporation technique by Box Behnken design. Three operating variables lipid concentration, Surfactant and Sonication time were found to have significant effect on the particle size, entrapment efficiency (EE) and zeta potential  of the SLN. The maximum EE was found to be 87.43% with particle size of 167.3nm and zeta potential of -22.77. The optimized batch was also analyzed for its morphological, physiochemical and ex vivo intestinal permeation properties. This work indicates that Penciclovir loaded in SLN could be better option for enhancing the permeability of Penciclovir in intestine as compared to existing marketed formulations.

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Published

2024-06-20

How to Cite

B. Arunprasath, Abhinandan Danodia, & Dibya lochan Mohanty. (2024). Development Optimization Characterization of Penciclovir Loaded Solid Lipid Nanoparticle for Enhancement of Oral Bioavailability . IJPAR JOURNAL, 13(2), 255–261. Retrieved from https://ijpar.com/ijpar/article/view/772

Issue

Vol. 13 No. 2 (2024): 2024 Volume - 13 Issue - 2

Section

Articles