Formulation and optimization of cisplatin liposomal drug delivery system

Abstract

In the present work an attempt is being made to provide for stable drug delivery system with or having improved therapeutic index for Cisplatin in form of lyophilized liposomes. By varying the composition of lipids six formulations of Liposomes were prepared and loaded by Cisplatin as a model drug using physical dispersion method for targeted delivery of this drug. Various evaluation parameters were studied for the prepared liposomes which includes encapsulation efficiency, particle size analysis, in-vitro drug release, stability studies etc. Because F5 has higher encapsulation effectiveness and a smaller particle size than the other formulations, it was determined to be the best choice. The phosphatidylcholine and cholesterol-containing formulation F5 satisfies the liposomal formulation criterion. More than 95.73% of the drug was released in 8 hours of in vitro testing, with 80.25% drug encapsulation efficiency.