Synthesis, Characterization and Biological evaluation of New Schiff’s Base Derivatives

Abstract

This manuscript presents the synthesis, characterization, and biological evaluation of novel Schiff’s base derivatives derived from aromatic aldehydes and amino acids. Schiff bases, known for their biological relevance and stability when linked to aryl groups, were synthesized using a condensation reaction facilitated by mildly acidic conditions to ensure optimal yields without compromising the nucleophilicity of the amines. The synthesized compounds were rigorously characterized using melting point determination, thin-layer chromatography (TLC), and infrared spectroscopy (IR). Their biological efficacy was assessed through in vitro antibacterial and antifungal assays, demonstrating considerable activity against common pathogenic strains such as Escherichia coli, Bacillus subtilis, and Candida albicans. The compounds exhibited a range of activities, with some showing comparable efficacy to standard antibiotics and antifungals. These findings suggest that Schiff’s bases could be potent candidates for drug development, offering a scaffold for further chemical enhancement and therapeutic application.