Formulation Development And Invitro Evaluation Of Quetiapine Fumarate Controlled Release Matrix Tablets

Abstract

The present investigation concerns the development of controlled release matrix tablet of Quetiapine Fumarate. Matrix tablet of Quetiapine Fumarate was formulated by using Eudragit S 100 and   HPMC grades as  a polymeric  matrix  forming  materials  in various  concentrations   to  study their  ability  to retard the release. All the formulations showed good flow properties such as angle of repose, bulk density, tapped density. The prepared tablets were shown good post compression parameters and they passed all the quality control evaluation parameters as per I.P limits. Among all the formulations F5 formulation showed maximum % drug release i.e., 98.73 % in 24 hours hence it is considered as optimized formulation F5 which contains HPMC K4 M. It followed Zero order release mechanism.