Synthesis and anticancer activity of some novel 3-[(2-substituted-6,7,8,9-tetrahydro-5H-cyclohepta[b]thieno [2,3-d]pyrimidin-4-YL)amino]propan-1-OL]

Abstract

The chemistry of pyrimidines and its derivatives has been studied for over a century due to their diverse biological activities. They possess Anticancer Activity. The conventional method of preparation of 3-[(2-substituted-6,7,8,9-tetrahydro-5H-cyclohepta[b]thieno[2,3-d]pyrimidin-4-yl)amino]propan-1-olwas compared with microwave assisted method with respect to their reaction time and yield. All the compounds synthesized were characterized by physical (Rf values, M.P., Molecular weight, molecular formula), spectral data (1H NMR, 13C NMR, MASS).The title compounds were screened for anticancer activity by MTT assay and analyzed statistically. Compounds showed considerable anticancer activity when compared with cyclophosphamide.