Formulation and evaluation of floating tablets containing for selected antibiotic

Abstract

Floating tablets were prepared using direct compression with varying ratios of Karaya gum, Carbopol, and Xanthan gum. The preformulation studies included drug description, solubility, pH, and compatibility testing through infrared spectroscopy. Post-compression evaluation parameters included weight variation, thickness, hardness, friability, drug content, tablet density, floating test, swelling index, and in vitro dissolution studies. Results indicated that the formulated tablets met all standard physicochemical parameters. Floating tests demonstrated that the tablets remained buoyant for over 14 hours, while swelling studies showed significant hydration and gel formation, contributing to controlled drug release. In vitro dissolution studies revealed satisfactory drug release profiles, with formulations F2, F5, F8, and F10 showing extended release patterns fitting the Higuchi model, indicative of a diffusion-controlled mechanism. Stability studies confirmed that the floating tablets remained stable under various storage conditions for up to 60 days. In conclusion, the developed Levofloxacin floating tablets demonstrated potential as an effective GRDDS, improving drug bioavailability and offering sustained release, making them suitable for clinical application.