Directly Compressible Forms Of Itraconazole By Spherical Agglomeration

Abstract

The present work deals with the spherical crystallization process by Spherical agglomeration method applied to Itraconazole, a novel Antifungaldrug. The object of present study was to prepare and characterize the spherical agglomeration of water insoluble non-steroidal anti-inflammatory drug. Itraconazole spherical agglomerates prepared with sodium alginate, which is hydrophilic polymer by using simple spherical agglomeration technique for enhancing micromeritic properties. The prepared Itraconazole spherical agglomerates were examined in terms of flow properties, particle size analysis, compression and dissolution behaviour. Physical characters of the crystals were studied for the morphology of crystals using scanning electron microscope (SEM), identification of polymorphism done by x-ray powder diffraction (XPRD) and for thermo dynamic properties using differential scanning colorimetry (DSC). The prepared agglomerates were improved the micromeritic properties, packability, wettability, solubility and compaction behaviour in comparison to pure Itraconazole drug.