Formulation development and invitro evaluation of quinethazone sustained release oral dry syrup (ds)
Keywords:
Dry syrup (DS), Quinethazone, Eudragit EPO etcAbstract
The aim of this present investigation was to develop Quinethazone sustained release dry syrup formulation. The formulations were evaluated for different parameters like taste evaluation, Micromeritic properties and % of drug release. It was concluded that the taste was completely masked and acceptable for patients. The taste masked syrup was prepared using three different suspending agents namely Ghatti gum, Eudragit EPO and Eudragit RLPO. The final formulation contained three different concentrations of each suspending agents. Then it was evaluated for different parameters like colour, odour, flow properties, % drug content, sedimentation volume, pH, redispersibility, viscosity and in- vitro drug release. From the results it was concluded that the formulation with suspending agent Eudragit EPO with 3% concentration showed highest sedimentation volume and better redispersibility which were very important parameter when once have to deal with syrup. The other parameters were also showed better results for the same suspending agent. So it was selected as an optimized suspending agent amongst three.