Formulation And In Vitro Evaluation of Controlled Release Matrix Tablets of Zidovudine

Abstract

Objective: This study aimed to develop and evaluate controlled-release matrix tablets of Zidovudine, with the goal of extending the drug’s release profile to enhance therapeutic efficacy and patient compliance.

Methods: Zidovudine matrix tablets were formulated using various polymers to achieve a controlled-release mechanism. The tablets were prepared through direct compression, and their physical properties—including hardness, friability, drug content, and weight uniformity—were assessed. In vitro dissolution studies were conducted under simulated gastrointestinal conditions to evaluate the release kinetics and determine the suitability of the matrix tablets for controlled drug delivery.

Results: The formulated matrix tablets exhibited satisfactory physical characteristics, including appropriate hardness and minimal friability. The in vitro dissolution studies revealed a prolonged and consistent release of Zidovudine, with the tablets demonstrating a controlled-release profile that effectively sustained drug release over an extended period. The release data indicated that the matrix tablets followed a controlled-release mechanism, with a steady drug release rate that met the desired therapeutic requirements.

Conclusion: The development of controlled-release matrix tablets for Zidovudine proved to be effective in providing a sustained release of the drug, potentially improving therapeutic efficacy and patient adherence by reducing dosing frequency. The results suggest that the matrix tablets are stable and capable of achieving the intended controlled-release profile.