A Review On Docking Studies On Newer Treatment Strategies For Jaundice Induced By AIH

Abstract

The immune system's primary role is to protect the host from infectious agents; however, its malfunction can lead to autoimmune diseases, wherein the immune system mistakenly attacks the body's own tissues. This research focuses on autoimmune hepatitis (AIH), a condition characterized by liver inflammation triggered by the immune response against liver cells, predominantly affecting women. The study examines the pathophysiology of AIH, highlighting the role of CD4+ T-lymphocytes and the cytokine interleukin-17 (IL-17) in mediating inflammation. Jaundice, a symptom of liver dysfunction resulting from excess bilirubin, is also explored, detailing its types and underlying causes including liver disease and hemolytic anemia. The research employs molecular docking techniques to investigate the potential of IL-17 inhibitors in mitigating autoimmune responses, emphasizing the importance of computational methods in understanding and treating autoimmune conditions. Furthermore, the paper discusses the role of serotonin in autoimmune inflammation and the therapeutic potential of selective serotonin reuptake inhibitors (SSRIs) in managing autoimmune diseases. This comprehensive study aims to elucidate the complex interactions between immune responses, liver health, and therapeutic interventions for autoimmune diseases.