Review on fentanyl: Mechanism and Pharmacology of fentanyl drug

Abstract

In this area, smaller quantities of Fentanyl were generally always given with one of a variety of IV hypnotics. The term neurolept anesthesia was essentially a combination of neuroleptic agents with inhalation anesthetics (fentanyl and higher doses of droperidol), with nitrous oxide and oxygen or not. This practice had become fairly common, first in the majority of western countries followed by the vast majority of Eastern European countries. The use of fentanyl in anesthesia became widely accepted with the publication of a paper in December 1969, in The New England Journal of Medicine, that described a study by Lowenstein et al. It wasn't long afterward that many randomized studies were performed over a 3-to-4-year period to assess high-dose morphine/oxygen anesthesia as a Technique For Critically Ill Patients Undergoing open heart surgery-and later major vascular surgery. Some of the increase use of this technique was attributed to remarkable stability of cardiovascular function in this group of critically ill patients.

Fentanyl is indicated for the management of breakthrough pain (which is brief occurrences of intense pain despite taking around-the-clock pain medication). It is only indicated for patients who are 18 years of age or older and are already on regularly scheduled doses of a narcotic (opiate) pain medication within the past seven days, who are tolerant to the effects of the narcotic pain medications. Fentanyl is a narcotic (opiate) analgesic, which is a type of medication that change the way the brain and nervous system respond to pain. Give it with your other pain medication(s). Do not discontinue your other pain medication(s) before or during your use of fentanyl.