Evaluation of Analgesic Activity of Ethanolic Leaf Extract of Madhuca Longifolia

Abstract

In this study, investigate the analgesic activity of the ethanolic leaf extract of Madhuca longifolia animal models using Eddy's hot plate method. In which to explore the analgesic activity of ethanolic leaf extract of Madhuca longifolia using Eddy's hot plate method. To compare the effect of ethanolic leaf extract of Madhuca longifolia with the commonly used analgesic drug pentazocin. This study was conducted by using Eddy's hot plate method. A total of 12 Adult swis albino mice were grouped into four groups of 4 animals in each group. These groups were Group I: Control (normal saline), Group II: Standard (Pentazoicin, 3mg per kg) Group III: Ethanolic root extract of Leaf extract of Madhuca longifolia(200mg per kg) & Group IV: Ethanolic root extract of Leaf extract of Madhuca longifolia(400mg per kg). The reaction time was recorded at 0, 30, 60 & 90 minutes after injecting normal saline, standard drug, and extract. Result: The increase in mean reaction time of the extract was statistically significant (p< 0.0001) at 30, 60, 90 and 120 min compared to that of the control. There was less increase in the reaction time of 400 mg of Leaf extract of Madhuca longifoliain treated group compared to that of the pentazocin-treated group at 30 min & 60 min points. Based on above rseult discussion ,the present study was conclude that the analgesic activity of 400 mg of Leaf extract of Madhuca longifoliain was significantly more than that of the control group. Peak analgesic activity occurred at 60 and 90 minutes.