Synthesis, characterization of certain new heterocyclic hybrids of pyrazoles and evaluation of their anti-inflammatory activity

Abstract

The work presented in this article consists of synthesis, characterization and biological evaluation of substituted pyrazole derivatives.  Pyrazole derivatives have been shown to have wide variety of pharmacological  activities like anti-inflammatory,  antidepressant  and anticonvulsant.  As combination  of biologically  active moieties into one molecule and synthesis of totally newer moieties have been the methods of research, the present study is an attempt to synthesize some novel pyrazole derivatives,  incorporating  various biologically  active aryl / aryloxy acid  derivatives,   such  as  ibuprofen,   diclofenac,   aceclofenac   as  well  as  potent  antibacterial   quinolones, norfloxacin and ciprofloxacin. All the compounds synthesized were evaluated for their anti-inflammatory (Carrageenan  induced  paw oedema method)  activity. The results obtained  were found to be compatible  with standard  literature  and standard  drug employed.  Hence,  the  obtained  derivatives  can be subjected  to further clinical studies to optimize their clinical efficacy.