Targeting On The Regulation On Testicular Spermatogenic Activity Against Monosodium Glutamate Adverse Effects

Abstract

Monosodium glutamate (MSG) is a well-known food additive that has been shown to be effective in causing male reproductive abnormalities. This common flavor enhancer is used extensively in many diets to improve flavor. There are various mechanisms through which it can cause reproductive dysfunctions. These include spermatogenic alteration, which can lead to abnormalities such as low sperm count, high sperm count, reduced live sperm and decreased sperm pH; oxidative damage, which can involve increased lipid peroxidation and decreased antioxidant enzyme activities; histological alteration, which can involve blood clots, distorted germ cells, and Sertoli cells; and gonadotropin imbalance, which can involve decreased levels of follicle-stimulating hormone, testosterone and luteinizing hormone. The different known pathways through which MSG may cause reproductive dysfunction are therefore covered in this review along with mitigation techniques for its harmful consequences